Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin
Chisq
Df
Pr(>Chisq)
(Intercept)
250.7924480
1
<0.0001
***
Study
3.2136720
1
0.07
ns
f39_gdm_new
0.5754347
1
0.4
ns
BMI
3.3368238
1
0.07
ns
Ethnicity_cauc
105.4219556
1
<0.0001
***
f10c_any_cig_1st_vst
49.1590682
1
<0.0001
***
GA_samp
164.6323095
1
<0.0001
***
Study:f39_gdm_new
1.8652579
1
0.2
ns
HPL
Chisq
Df
Pr(>Chisq)
(Intercept)
150.8759535
1
<0.0001
***
Study
7.3986291
1
0.007
**
f39_gdm_new
0.4357432
1
0.5
ns
BMI
236.2094019
1
<0.0001
***
Ethnicity_cauc
5.5165373
1
0.02
*
f10c_any_cig_1st_vst
0.9176455
1
0.3
ns
GA_samp
2601.9722143
1
<0.0001
***
Study:f39_gdm_new
1.4845286
1
0.2
ns
GH2
Chisq
Df
Pr(>Chisq)
(Intercept)
251.096669
1
<0.0001
***
Study
1.107622
1
0.3
ns
f39_gdm_new
1.386104
1
0.2
ns
BMI
87.622496
1
<0.0001
***
Ethnicity_cauc
3.246832
1
0.07
ns
f10c_any_cig_1st_vst
1.039153
1
0.3
ns
GA_samp
1032.266869
1
<0.0001
***
Study:f39_gdm_new
3.376951
1
0.07
ns
Insulin
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
21.326
21.326
<0.0001
***
3
f39_gdm_new
1
Inf
33.726
33.726
<0.0001
***
4
BMI
1
Inf
330.722
330.722
<0.0001
***
5
Ethnicity_cauc
1
Inf
25.046
25.046
<0.0001
***
6
f10c_any_cig_1st_vst
1
Inf
3.158
3.158
0.08
ns
7
GA_samp
1
Inf
2.506
2.506
0.1
ns
2
Study:f39_gdm_new
1
Inf
4.089
4.089
0.04
*
HOMA.IR
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
36.051
36.051
<0.0001
***
3
f39_gdm_new
1
Inf
32.027
32.027
<0.0001
***
4
BMI
1
Inf
316.807
316.807
<0.0001
***
5
Ethnicity_cauc
1
Inf
24.882
24.882
<0.0001
***
6
f10c_any_cig_1st_vst
1
Inf
2.618
2.618
0.1
ns
7
GA_samp
1
Inf
1.602
1.602
0.2
ns
2
Study:f39_gdm_new
1
Inf
4.361
4.361
0.04
*
GLUC3_mmol.L
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
53.182
53.182
<0.0001
***
3
f39_gdm_new
1
Inf
4.345
4.345
0.04
*
4
BMI
1
Inf
11.449
11.449
0.0007
***
5
Ethnicity_cauc
1
Inf
0.718
0.718
0.4
ns
6
f10c_any_cig_1st_vst
1
Inf
0.028
0.028
0.9
ns
7
GA_samp
1
Inf
0.278
0.278
0.6
ns
2
Study:f39_gdm_new
1
Inf
1.558
1.558
0.2
ns
62.2.2 Model summary
Ratio of Geometric means (95% CI)
Prolactin
Var
Effect
P
(Intercept)
2.75 (2.39, 3.12)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.12
f39_gdm_newGDM
-0.11 (-0.35, 0.13)
0.36
StudySTOP
-0.08 (-0.21, 0.05)
0.23
GA_samp
0.14 (0.12, 0.16)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.75
f39_gdm_newGDM:StudySTOP
0.16 (-0.07, 0.38)
0.17
Folate:StudySTOP
0.00 (-0.00, 0.00)
0.10
HPL
Var
Effect
P
(Intercept)
0.65 (0.46, 0.84)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.58
f39_gdm_newGDM
-0.11 (-0.23, 0.01)
0.07
StudySTOP
0.10 (0.03, 0.17)
0.004
GA_samp
0.29 (0.28, 0.30)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.28
f39_gdm_newGDM:StudySTOP
0.06 (-0.05, 0.17)
0.31
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.89
GH2
Var
Effect
P
(Intercept)
-2.57 (-2.82, -2.32)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.37
f39_gdm_newGDM
-0.17 (-0.34, 0.00)
0.05
StudySTOP
-0.01 (-0.11, 0.08)
0.77
GA_samp
0.26 (0.25, 0.28)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.65
f39_gdm_newGDM:StudySTOP
0.17 (0.00, 0.33)
0.05
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.89
Insulin
Var
Effect
P
(Intercept)
2.45 (1.99, 2.91)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.56
f39_gdm_newGDM
0.94 (0.44, 1.44)
0.0002
StudySTOP
-0.17 (-0.36, 0.02)
0.07
GA_samp
0.02 (-0.01, 0.05)
0.24
Folate:f39_gdm_newGDM
-0.00 (-0.01, 0.00)
0.27
f39_gdm_newGDM:StudySTOP
-0.42 (-0.98, 0.13)
0.14
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.24
Folate:f39_gdm_newGDM:StudySTOP
0.00 (-0.00, 0.01)
0.38
HOMA.IR
Var
Effect
P
(Intercept)
1.09 (0.60, 1.58)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.54
f39_gdm_newGDM
1.08 (0.52, 1.65)
0.0002
StudySTOP
-0.32 (-0.51, -0.12)
0.002
GA_samp
0.01 (-0.02, 0.04)
0.39
Folate:f39_gdm_newGDM
-0.00 (-0.01, 0.00)
0.18
f39_gdm_newGDM:StudySTOP
-0.51 (-1.13, 0.10)
0.10
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.25
Folate:f39_gdm_newGDM:StudySTOP
0.00 (-0.00, 0.01)
0.33
GLUC3_mmol.L
Var
Effect
P
(Intercept)
1.73 (1.63, 1.82)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.67
f39_gdm_newGDM
0.16 (0.03, 0.30)
0.02
StudySTOP
-0.15 (-0.18, -0.11)
<0.0001
GA_samp
-0.00 (-0.01, 0.00)
0.44
Folate:f39_gdm_newGDM
-0.00 (-0.00, -0.00)
0.03
f39_gdm_newGDM:StudySTOP
-0.07 (-0.19, 0.04)
0.20
Folate:StudySTOP
0.00 (-0.00, 0.00)
0.61
62.2.3 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Serum folate concentration (nM) and may be misleading when interaction term is involved.
Prolactin
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
97.77404
7.328399
86.89088
84.24089
113.4813
STOP
non-GDM
95.21737
6.830184
73.12151
82.53345
109.8506
SCOPE
GDM
88.89601
11.031476
534.09053
69.66477
113.4361
STOP
GDM
101.42073
8.859190
156.34178
85.34803
120.5202
HPL
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
89.48653
2.397042
155.4415
84.87464
94.34902
STOP
non-GDM
98.99553
2.442050
113.5757
94.27396
103.95357
SCOPE
GDM
82.59212
4.500140
823.2588
74.21497
91.91486
STOP
GDM
96.91737
3.552318
432.8746
90.18100
104.15695
GH2
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
2.358518
0.0675800
372.7572
2.229306
2.495219
STOP
non-GDM
2.316497
0.0571383
254.7097
2.206662
2.431798
SCOPE
GDM
2.022779
0.1546622
1400.9025
1.741041
2.350107
STOP
GDM
2.343339
0.1019796
804.3136
2.151473
2.552315
Insulin
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
14.21264
0.7009927
Inf
12.90303
15.65516
STOP
non-GDM
11.34214
0.4379906
Inf
10.51538
12.23391
SCOPE
GDM
32.57401
5.7010512
Inf
23.11508
45.90365
STOP
GDM
18.90218
1.4998809
Inf
16.17966
22.08281
HOMA.IR
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
3.444485
0.1804177
Inf
3.108418
3.816885
STOP
non-GDM
2.366071
0.0958502
Inf
2.185472
2.561593
SCOPE
GDM
8.779249
1.7041093
Inf
6.001138
12.843433
STOP
GDM
4.100215
0.3501282
Inf
3.468329
4.847223
GLUC3_mmol.L
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
5.431002
0.0507757
Inf
5.332390
5.531438
STOP
non-GDM
4.701537
0.0367122
Inf
4.630130
4.774045
SCOPE
GDM
6.129766
0.3417906
Inf
5.495177
6.837639
STOP
GDM
4.927915
0.0698577
Inf
4.792881
5.066753
62.2.4 Comparisons
62.2.4.1 Within Groups
Effect for every 50 unit increase in Serum folate concentration (nM).
Hormone
Contrast
Study
f39_gdm_new
Ratio of Geometric means (95% CI)
P-value
Prolactin
Folate40.2 / Folate39.2
SCOPE
non-GDM
0.999 (0.998, 1.000)
0.1
Prolactin
Folate40.2 / Folate39.2
STOP
non-GDM
1.000 (0.999, 1.001)
0.5
Prolactin
Folate40.2 / Folate39.2
SCOPE
GDM
0.999 (0.997, 1.002)
0.6
Prolactin
Folate40.2 / Folate39.2
STOP
GDM
1.001 (0.998, 1.003)
0.5
HPL
Folate40.2 / Folate39.2
SCOPE
non-GDM
1.000 (0.999, 1.000)
0.6
HPL
Folate40.2 / Folate39.2
STOP
non-GDM
1.000 (0.999, 1.000)
0.4
HPL
Folate40.2 / Folate39.2
SCOPE
GDM
1.001 (0.999, 1.002)
0.5
HPL
Folate40.2 / Folate39.2
STOP
GDM
1.000 (0.999, 1.002)
0.5
GH2
Folate40.2 / Folate39.2
SCOPE
non-GDM
1.000 (0.999, 1.001)
0.4
GH2
Folate40.2 / Folate39.2
STOP
non-GDM
0.999 (0.999, 1.000)
0.2
GH2
Folate40.2 / Folate39.2
SCOPE
GDM
1.000 (0.998, 1.002)
1.0
GH2
Folate40.2 / Folate39.2
STOP
GDM
1.000 (0.998, 1.002)
0.9
Insulin
Folate40.2 / Folate39.2
SCOPE
non-GDM
0.999 (0.997, 1.001)
0.6
Insulin
Folate40.2 / Folate39.2
STOP
non-GDM
0.998 (0.997, 0.999)
0.002
Insulin
Folate40.2 / Folate39.2
SCOPE
GDM
0.997 (0.992, 1.001)
0.1
Insulin
Folate40.2 / Folate39.2
STOP
GDM
0.998 (0.995, 1.001)
0.2
HOMA.IR
Folate40.2 / Folate39.2
SCOPE
non-GDM
0.999 (0.997, 1.001)
0.5
HOMA.IR
Folate40.2 / Folate39.2
STOP
non-GDM
0.998 (0.997, 0.999)
0.002
HOMA.IR
Folate40.2 / Folate39.2
SCOPE
GDM
0.996 (0.991, 1.001)
0.09
HOMA.IR
Folate40.2 / Folate39.2
STOP
GDM
0.997 (0.994, 1.001)
0.1
GLUC3_mmol.L
Folate40.2 / Folate39.2
SCOPE
non-GDM
1.000 (1.000, 1.000)
0.7
GLUC3_mmol.L
Folate40.2 / Folate39.2
STOP
non-GDM
1.000 (1.000, 1.000)
0.7
GLUC3_mmol.L
Folate40.2 / Folate39.2
SCOPE
GDM
0.999 (0.998, 1.000)
0.05
GLUC3_mmol.L
Folate40.2 / Folate39.2
STOP
GDM
0.999 (0.998, 1.000)
0.01
62.2.4.2 Between Groups
Below are comparisons of the differences in the change in Serum folate concentration (nM) between groups. I.e. whether the change in Serum folate concentration (nM) are different between groups.